Inhaled Treprostinil Drug Delivery During Mechanical Ventilation and Spontaneous Breathing Using Two Different Nebulizers

Spontaneous breathing during mechanical ventilation in ARDS

The objective of mechanical ventilation used in the management of Acute Respiratory Distress Syndrome (ARDS) is to ensure adequate tissue oxygenation and alveolar ventilation while limiting the patients’ work of breathing and preventing further damage to the lungs. Although the “partial support” ventilation modes were initially developed to assist weaning or liberation from supported ventilatio...

In vitro delivery of aerosolized treprostinil via modern mechanical ventilation.

BACKGROUND The Tyvaso Inhalation System is a hand-held nebulizer system used to administer treprostinil, an approved therapy for pulmonary arterial hypertension. Our goal was to establish an in vitro method for delivering a standard dose of treprostinil through a ventilator circuit and artificial airway. METHODS An AeroTech II jet nebulizer (continuous air flow at 10 L/min; Biodex Medical Sys...

Gas exchange during mechanical ventilation and spontaneous breathing. Intermittent mandatory ventilation after open heart surgery.

Pulmonary gas exchange rates in eight patients after open heart surgery were studied during weaning from the ventilator. We investigated continuous positive pressure ventilation (CPPV), intermittent mandatory ventilation (IMV) and spontaneous breathing with continuous positive airway pressure (CPAP). During each mode of ventilation we measured: CO2 production (VCO2), O2 consumption (VO2), cardi...

Inhaled bronchodilator administration during mechanical ventilation.

Inhaled bronchodilators are routinely administered to mechanically ventilated patients to relieve dyspnea and reverse bronchoconstriction. A lower percentage of the nominal dose reaches the lower respiratory tract in a mechanically ventilated patient than in a nonintubated subject, but attention to device selection, administration technique, dosing, and patient-ventilator interface can increase...

The Breathing-Book Spontaneous breathing during artificial ventilation